PAC-MAN (Prophylactic Anti-viral CRISPR in huMAN cells) technology, when tested under laboratory conditions on synthetic SARS-CoV-2 it decreased the count of the virus by 90%.

Viruses come in many forms: DNA and RNA, double-stranded and single-stranded. Approximately two thirds of the viruses that infect humans are RNA viruses. Surprisingly, there are very few treatments available for RNA viruses. The RNA therapies that do exist typically use small molecules to interfere with viral replication. However, this approach does not work for newly emerging viruses, or ones that are evolving rapidly, like COVID-19.

Scientists have now found a way to fight RNA viruses within human cells, and unsurprisingly CRISPR may play a role. CRISPR is well-known as a Nobel-prize winning laboratory tool that can be used to…


In March 2021 I launched the Tej Kohli & Ruit Foundation to take low-cost cataract surgeries out into poor and remote communities in Nepal, Indonesia, Ethiopia, Tanzania, Myanmar, India and China. Working with my co-founder Dr Sanduk Ruit, I hope to cure 300,000 of cataract blindness by 2026.

The prevalence, causes and impact of blindness are simultaneously well-documented whilst also being poorly understood by the general public. 90% of all blindness occurs in low-income countries, where those who suffer are quite literally ‘out of sight’ from the rest of the world.

In this #TejTalks blog post I will curate the…


Tej Kohli is founder of the Tej Kohli Foundation which is committed to ending needless poverty-driven blindness in low income countries. Tej Kohli is also co-founder of the Tej Kohli & Ruit Foundation which is dedicated to making grassroots interventions to cure cataract blindness in poor communities. Tej Kohli is on Twitter as MrTejKohli and regularly posts blogs as #TejTalks.

The second wave of COVID-19 has struck India and the situation is devastating. Apart from COVID-19 infections and deaths, a series of fungal infections has also begun to take root. The ‘black fungus’ is known to medical experts as Mucormycosis


Exponential growth is important. In May 2020 I wrote a #TejTalks blog about how my Kohli Ventures investment vehicle is focused on getting in early on exponential growth opportunities. Then in an interview on CityAM.com I talked about how I am chasing the second wave of CRISPR-Cas9 because I believe that the technology is still in the early stages of exponential growth.

Exponential technological progress matters because it is well established that technological change improves overall wealth in a society and that in turn this reduces poverty and extreme poverty. The biggest cause of the needless blindness that my not-for-profit…


When Murathi Parsi of the Kapilavastu District of Nepal went blind, surgery was out of reach. Despite living only one hour away from an eye hospital, the family simply did not have NRS 8,000 (approx USD 70) needed for her surgery. Her husband and her son, both daily wage earners, had to make do with odd jobs in construction. With almost seven mouths to feed along with some household debt, saving up the amount needed for Murathi’s operation seemed like an insurmountable task.

Lucky for Murathi, one day when her husband was visiting her daughter’s home in Butwal, they heard…


95 million people worldwide are affected by blindness or severe visual impairment due to cataracts according to the WHO. Nearly 90% of the world’s blind live in the poorest countries in the world. Cataracts in particular are disproportionately prevalent in low-and-middle-income countries, where they account for 50% of all blindness, compared to just 5% of blindness in the West. The truth is that cataracts are not that difficult or even expensive to cure when people have access to affordable eye care.

Unfortunately, most people do not.

The impact is that millions of people worldwide live with blindness despite the fact…


I think that what AI is still missing is an intuitive user interface that entrepreneurs can 'plug in' to to access the benefits of AI muck like the Internet today. IBM's open source Watson is a big step in that direction but we're still a long way from your 'man on the street' entrepreneur being able to build AI-powered applications.


Leber’s is the number one genetic cause of blindness in childhood.

Leber Congenital Amaurosis is an eye disorder that primarily affects the retina, which is the specialized tissue at the back of the eye that detects light and colour. People with the disorder typically have severe visual impairment beginning in infancy, making Leber’s the number one genetic cause of blindness in childhood. It is estimated that Leber’s affects approximately 15,000 people in the West world, and many more in the rest of the world.

Now a person with Leber’s has become the first to receive a CRISPR–Cas9 gene therapy administered directly into their body. The treatment is part of a landmark…


Nzambi Matee is a Nairobi-based entrepreneur and inventor who is the founder of a startup which recycles plastic waste into bricks that are stronger than concrete. Nzambi launched her company initiated following the development of a prototype machine that turns discarded plastic into paving stones. Each day her factory can produce 1,500 churned plastic pavers, which are prized locally not just for the quality, but for how affordable they are.

“It is absurd that we still have this problem of providing decent shelter — a basic human need. Plastic is a material that is misused and misunderstood. …


At it’s heart artificial intelligence is about efficiency and productivity. In a world of omnipresent AI that is present across every segment of economic activity, people will be able to do more with less. This leads to greater economic wealth, health and also increased leisure and family time.

For evidence of the economic and social benefits that AI will bring, look no further than the fact that workers in richer countries tend to work fewer hours than workers in poorer countries. …

Tej Kohli

Technologist, entrepreneur & investor interested in deep tech & e-commerce. Also owner of Zibel Real Estate & founder of the not-for-profit Tej Kohli Foundation

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